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<i>Cerasus yedoensis<_i> (Mats.) Y� et Li

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Methionine Adenosyltransferase (MAT) (32) Apoptosis (1) Biochemical Assay Reagents (1) CDK (2) Fluorescent Dye (1) Histone Methyltransferase (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (1) nAChR (1) NF-κB (1) p38 MAPK (1) Reactive Oxygen Species (1) SARS-CoV (1) Sirtuin (1) Small Interfering RNA (siRNA) (9) Somatostatin Receptor (5) Wnt (1)
By Research Areas:	Cancer (40) Infection (1) Inflammation/Immunology (1) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (3) siRNAs (9)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Methionine Adenosyltransferase (MAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10103

Neoschaftoside	Others	Others
Neoschaftoside is a natural product that can be isolated from Viola yedoensis .

HY-170500

MAT2A-IN-17	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-17 is a potent *MAT2A* inhibitor with an IC₅₀ < 100 nM. MAT2A-IN-17 can be used in the study of cancer .

HY-N12269

Madolin U	Others	Others
Madolin U is a germacrane sesquiterpene isolated from the herb of Viola yedoensis .

HY-N12265

Versicolactone B	Others	Inflammation/Immunology
Versicolactone B is a sesquiterpene that can be isolated from Viola yedoensis. Versicolactone B exhibits anti-complement activity against the classical pathway and the alternative pathway .

HY-149915

MAT2A-IN-10	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-10 (Compound 28) is an orally active *MAT2A* inhibitor with an IC₅₀ of 26 nM. MAT2A-IN-10 can be used for the research of cancer .

HY-170503

MAT2A-IN-20	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-20 (Compound A49) is an inhibitor for methionine adenosyltransferase 2A (MAT2A) with an IC₅₀ ≤50 nM. MAT2A-IN-20 inhibits human UGT1A1 with an IC₅₀ of 28.45 μM. MAT2A-IN-20 exhibits antitumor in mouse models .

HY-162135

MAT2A-IN-14	Methionine Adenosyltransferase (MAT) Reactive Oxygen Species	Cancer
MAT2A-IN-14 (compound H3) is a *MAT2A* inhibitor, and generates reactive oxygen species after sonication to specifically degrade cellular MAT2A via rapid oxidative reactions. Combination of MAT2A-IN-14 and sonication induces 87% MAT2A depletion in human colon cancer cell .

HY-170905S

MAT2A-IN-22	Methionine Adenosyltransferase (MAT) Isotope-Labeled Compounds	Cancer
MAT2A-IN-22 (Compound 29-1) is a BBB-penetrable and orally active *MAT2A* inhibitor with an IC₅₀ of 4 nM. MAT2A-IN-22 shows selectivity and inhibitory activity against MTAP-deficient cancer cell lines. MAT2A-IN-22 has anti-tumor effects .

HY-161298

MAT2A-IN-15	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-15 (compound 8) is an inhibitor of *MAT2A* .

HY-144185

MAT2A-IN-7	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-7 is a potent inhibitor of *MAT2A. The expression level of MAT2A is abnormally elevated in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-7 reduces the proliferative activity of MTAP-deficient cancer cells. MAT*2A-IN-7 has the potential for the potential for the research of cancer diseases (extracted from patent WO2021254529A1, compound 24) .

HY-144184

MAT2A-IN-6	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-6 is a potent inhibitor of *MAT2A. The expression level of MAT2A is abnormally elevated in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-6 reduces the proliferative activity of MTAP-deficient cancer cells. MAT*2A-IN-6 has the potential for the potential for the research of cancer diseases (extracted from patent WO2021254529A1, compound 18) .

HY-144181

MAT2A-IN-5	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-5 is a potent inhibitor of *MAT2A. The expression level of MAT2A is abnormally elevated in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-5 reduces the proliferative activity of MTAP-deficient cancer cells. MAT*2A-IN-5 has the potential for the potential for the research of cancer diseases (extracted from patent WO2021254529A1, compound 1) .

HY-142929

MAT2A-IN-2	Somatostatin Receptor	Cancer
MAT2A-IN-2 is a potent inhibitor of *MAT2A. The expression level of MAT2A is abnormally high in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-2 reduces the proliferative activity of MTAP-deficient cancer cells. MAT*2A-IN-2 has the potential for the research of cancer diseases (extracted from patent WO2020243376A1, compound 172) .

HY-142928

MAT2A-IN-1	Somatostatin Receptor	Cancer
MAT2A-IN-1 is a potent inhibitor of *MAT2A. The expression level of MAT2A is abnormally high in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-1 reduces the proliferative activity of MTAP-deficient cancer cells. MAT*2A-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021139775A1, compound 64) .

HY-142930

MAT2A-IN-3	Somatostatin Receptor	Cancer
MAT2A-IN-3 is a potent inhibitor of *MAT2A. The expression level of MAT2A is abnormally high in several types of tumors, including gastric, colon, liver and pancreatic cancers. MAT2A-IN-3 reduces the proliferative activity of MTAP-deficient cancer cells. MAT*2A-IN-3 has the potential for the research of cancer diseases (extracted from patent WO2019191470A1, compound 265) .

HY-168445

MAT2A-IN-21	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-21 (compound 28) is a potent methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC₅₀ of 49 nM. MAT2A-IN-21 selectivity inhibits MTAP-deficient cancer cells .

HY-162010

MAT2A-IN-13	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-13 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with a favorable pharmacokinetic profile. MAT2A-IN-13 shows in vivo potency in an HCT-116 MTAP-deleted xenograft model. MAT2A-IN-13 can be used for MTAP-Deleted tumors treatment research .

HY-144179

MAT2A-IN-4	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-4 is a methionine adenosyltransferase 2A (MAT2A) inhibitor extracted from patent WO2020123395A1 compound 426 . MAT2A-IN-4 can be used for the research of cancer .

HY-173281

MAT2A-IN-24	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-24 (Compound 9) is an inhibitor of methionine adenosyltransferase 2a (MAT2a). The IC₅₀ value for the inhibition of *MAT2a* is 20 nM, and the IC₅₀ value for the antiproliferative activity against HAP1MTAP–/– cells is 10 nM. MAT2A-IN-24 can be used in the research field of tumor diseases associated with MTAP deficiency .

HY-170906S

MAT2A-IN-23	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-23 (compound 39) is a *MAT2A* inhibitor, with an IC₅₀ of 4 nM. MAT2A-IN-23 inhibits SAM in the HCT-116 (MTAP ^−/−) and in the HCT-116 WT cell line with IC₅₀s of 3 and 2 nM, respectively. MAT2A-IN-23 inhibits SDMA in the HCT-116 (MTAP ^−/−) and in the HCT-116 WT cell line with IC₅₀s of 2 and >3000 nM, respectively. MAT2A-IN-23 inhibits HCT-116 (MTAP ^−/−) cell proliferation with with an IC₅₀ of 47 nM .

HY-155148

MAT2A-IN-11	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A Allosteric inhibitor 1 (compound 5) is a MAT2A selective inhibitor of methionine adenosyltransferase (MAT) with an IC₅₀ of 6.8 nM .

HY-170501

MAT2A-IN-18	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-18 (Compound 15) is an inhibitor for methionine adenosyltransferase 2A (MAT2A) with an IC₅₀≤50 nM .

HY-170502

MAT2A-IN-19	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-19 (Compound I-3) is an inhibitor for methionine adenosyltransferase 2A (MAT2A) with an IC₅₀ of 32.93 nM .

HY-170421

MAT2A-IN-16	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A-IN-16 is a *MAT2A* inhibitor and inhibits cell proliferation of MTAP ^-/- HCT-116 cells (IC₅₀: 20 nM) .

HY-112569

MAT2A inhibitor 2	Methionine Adenosyltransferase (MAT) NF-κB p38 MAPK	Cancer
MAT2A inhibitor 2 is an inhibitor of methionine adenosine transferase 2A (MAT2A) with oral activity. MAT2A inhibitor 2 can be used in osteoporosis study

HY-139536

MAT2A inhibitor 4	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A inhibitor 4 is an inhibitor of the catalytic subunit of methionine S-adenosyltransferase-2 (MAT2A). MAT2A inhibitor 4 can be used for the research of cancer .

HY-163656

MAT2A inhibitor 5	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A inhibitor 5(compound 39) is an orally active, selectivity and blood-brain permeability inhibitor of *MAT2A* with the IC₅₀ of 11 nM. MAT2A inhibitor 5 inhibits tumor cell growth in vivo .

HY-139139

MAT2A inhibitor 3	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A inhibitor 3 is a methionine adenosyltransferase 2A (MAT2A) inhibitor extracted from patent WO2020123395A1, compound 24, has an IC₅₀ of <200 nM. MAT2A inhibitor 3 can be used for the research of cancers .

HY-155149

MAT2A-IN-12	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A Allosteric inhibitor 2 is a potent and selective MAT2A allosteric inhibitor with an IC₅₀ of 5 nM. MAT2A Allosteric inhibitor 2 shows nanomolar activity (IC₅₀=5 μM) in the the proliferation assay (MTAP ^-/- cell line) .

HY-159156

MAT2A inhibitor 6	Methionine Adenosyltransferase (MAT) Apoptosis Fluorescent Dye	Cancer
MAT2A inhibitor 6 (Compound 3N-h) is a specific *MAT2A* inhibitor with oral activity and yellow fluorescence (IC₅₀=26 nM), capable of visualizing MAT2A both in vitro and in vivo (λex = 430 nm, λem = 585 nm). MAT2A inhibitor 6 can induce apoptosis and has anticancer activity, which can be used in cancer research .

HY-158143

PRMT5-IN-34	Histone Methyltransferase	Cancer
PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT) .

HY-RS08167

MAT2A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAT2A Human Pre-designed siRNA Set A contains three designed siRNAs for MAT2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAT2A Human Pre-designed siRNA Set A MAT2A Human Pre-designed siRNA Set A

HY-RS20986

Mat1a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mat1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mat1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mat1a Mouse Pre-designed siRNA Set A Mat1a Mouse Pre-designed siRNA Set A

HY-RS23017

Mat2a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mat2a Rat Pre-designed siRNA Set A contains three designed siRNAs for Mat2a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mat2a Rat Pre-designed siRNA Set A Mat2a Rat Pre-designed siRNA Set A

HY-RS27503

Mat1a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mat1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Mat1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mat1a Rat Pre-designed siRNA Set A Mat1a Rat Pre-designed siRNA Set A

HY-RS08166

MAT1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAT1A Human Pre-designed siRNA Set A contains three designed siRNAs for MAT1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAT1A Human Pre-designed siRNA Set A MAT1A Human Pre-designed siRNA Set A

HY-RS16583

Mat2a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mat2a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mat2a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mat2a Mouse Pre-designed siRNA Set A Mat2a Mouse Pre-designed siRNA Set A

HY-RS27504

Mat2b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mat2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Mat2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mat2b Rat Pre-designed siRNA Set A Mat2b Rat Pre-designed siRNA Set A

HY-RS08168

MAT2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAT2B Human Pre-designed siRNA Set A contains three designed siRNAs for MAT2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAT2B Human Pre-designed siRNA Set A MAT2B Human Pre-designed siRNA Set A

HY-RS20987

Mat2b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mat2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mat2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mat2b Mouse Pre-designed siRNA Set A Mat2b Mouse Pre-designed siRNA Set A

HY-136144

FIDAS-5 3 Publications Verification	Methionine Adenosyltransferase (MAT)	Cancer
FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC₅₀ of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for *MAT2A* binding. FIDAS-5 has anticancer activities .

HY-136145

FIDAS-3	Wnt	Cancer
FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC₅₀ of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for *MAT2A* binding. FIDAS-3 has anticancer activities .

HY-107778

PF-9366 10+ Cited Publications	Methionine Adenosyltransferase (MAT)	Cancer
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC₅₀ of 420 nM and a K_d of 170 nM.

HY-112131

MAT2A inhibitor 1 1 Publications Verification	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A inhibitor 1 is a methionine adenosyltransferase 2A (MATA2) inhibitor with an IC₅₀ less than l00 nM .

HY-138630

AG-270 3 Publications Verification	Methionine Adenosyltransferase (MAT)	Cancer
AG-270 is an allosteric, noncompetitive, first-in-class, reversible and orally active *MAT2A* inhibitor, with an IC₅₀ of 14 nM .

HY-169257

SCR-7952	Methionine Adenosyltransferase (MAT)	Cancer
SCR-7952 is a *MAT2A* inhibitor, with IC₅₀ of 18.7 nM. SCR-7952 can be used in anti-cancer research .

HY-P4129

*Rabies Virus Matrix Protein Fragment(RV-MAT)*	nAChR	Others
Rabies Virus Matrix Protein Fragment (RV-MAT) is a polypeptide. Rabies Virus Matrix Protein Fragment targets the acetylcholine receptor (AChR) that exists on the cell surface .

HY-162353

AZ'9567	Methionine Adenosyltransferase (MAT)	Cancer
AZ9567 is a potent *MAT2A* inhibitor. AZ9567 exhibits antiproliferative activity against MTAP KO HCT116 cells with a pIC₅₀ of 8.9 .

HY-157154

MAT-POS-e194df51-1	SARS-CoV	Infection
MAT-POS-e194df51-1 is an orally active, non-covalent and non-peptide SARS-CoV-2 main protease (M ^pro) inhibitor with an IC₅₀ value of 37nM. MAT-POS-e194df51-1 is cytotoxic with EC₅₀ values of 64 nM and 126 nM in A549-ACE2-TMPRSS2 cells and HeLa -ACE2 cells, respectively .

HY-W763806

Zein	Biochemical Assay Reagents	Others
Zein is a plant protein‐based polymer, can be used to prepare nanofibrous mats through electrospun. Zein has good cell compatibility and easy fabrication ability, and can be used in drug delivery systems .

Cat. No.	Product Name	Type

HY-W763806

Zein	Native Proteins
Zein is a plant protein‐based polymer, can be used to prepare nanofibrous mats through electrospun. Zein has good cell compatibility and easy fabrication ability, and can be used in drug delivery systems .

Cat. No.	Product Name	Target	Research Area

HY-P4129

*Rabies Virus Matrix Protein Fragment(RV-MAT)*	nAChR	Others
Rabies Virus Matrix Protein Fragment (RV-MAT) is a polypeptide. Rabies Virus Matrix Protein Fragment targets the acetylcholine receptor (AChR) that exists on the cell surface .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10103

Neoschaftoside	Flavonoids Classification of Application Fields Flavones Source classification Ranunculaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields	Others
Neoschaftoside is a natural product that can be isolated from Viola yedoensis .

HY-N12269

Madolin U	Structural Classification Viola philippica Cav. Terpenoids Sesquiterpenes Source classification Violaceae Plants	Others
Madolin U is a germacrane sesquiterpene isolated from the herb of Viola yedoensis .

HY-N12265

Versicolactone B	Structural Classification Human Gut Microbiota Metabolites Viola philippica Cav. Microorganisms Terpenoids Sesquiterpenes Source classification Violaceae Plants Endogenous metabolite	Others
Versicolactone B is a sesquiterpene that can be isolated from Viola yedoensis. Versicolactone B exhibits anti-complement activity against the classical pathway and the alternative pathway .

HY-N8639

Chrysin 8-C-β-D-glucoside	Structural Classification Flavonoids Flavones Source classification Rosaceae Plants Prunus avium	Others
Chrysin 8-C-β-D-glucoside is a natural compound isolated from the herbs of Psidium guajava .

Cat. No.	Product Name	Chemical Structure

HY-170905S

MAT2A-IN-22
MAT2A-IN-22 (Compound 29-1) is a BBB-penetrable and orally active *MAT2A* inhibitor with an IC₅₀ of 4 nM. MAT2A-IN-22 shows selectivity and inhibitory activity against MTAP-deficient cancer cell lines. MAT2A-IN-22 has anti-tumor effects .

HY-170906S

MAT2A-IN-23

MAT2A-IN-23 (compound 39) is a MAT2A inhibitor, with an IC₅₀ of 4 nM. MAT2A-IN-23 inhibits SAM in the HCT-116 (MTAP ^−/−) and in the HCT-116 WT cell line with IC₅₀s of 3 and 2 nM, respectively. MAT2A-IN-23 inhibits SDMA in the HCT-116 (MTAP ^−/−) and in the HCT-116 WT cell line with IC₅₀s of 2 and >3000 nM, respectively. MAT2A-IN-23 inhibits HCT-116 (MTAP ^−/−) cell proliferation with with an IC₅₀ of 47 nM .

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<i>Cerasus yedoensis<_i> (Mats.) Y� et Li

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products